Estrumate is approved for the following uses in beef cow, lactating dairy cows and replacement beef and dairy heifers: For unobserved or non-detected estrus, treatment of pyometra, chronic endometritis, treatment of mummified fetus, treatment of luteal cysts and for synchronizing estrus. Estrumate is also used for termination of unwanted pregnancies. Estrumate can be used with Fertagyl (gonadorelin) to synchonize estrous cycles for fixed time artificial insemination in lactating dairy cows.