Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, shake well, and administer 3 mL without delay. Calves: Remove needle from syringe and administer a single 3-mL dose into the back of the calf’s mouth. Vaccination should occur as soon as possible after birth because susceptible calves are at risk as soon as they are born. Vaccination of calves older than 1 day may not be effective. Cows: Healthy cows should receive two 3-mL intramuscular doses administered 3-6 weeks apart during late pregnancy. Ideally, the second dose should be administered within 30 days prior to calving. In accordance with Beef Quality Assurance guidelines, this product should be administered in the muscular region of the neck. Historically, revaccination with two doses at each pregnancy has been recommended. The need for this booster vaccination has not been established for this product. For advice on revaccination frequency, contact your veterinarian.